Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azido-PEG8-NHS ester is an 8 unit PEG linker with cleavable properties, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also serves as a PEG- and Alkyl/ether-based PROTAC linker, enabling its utilization in the synthesis of PROTACs[2].
Description | Azido-PEG8-NHS ester is an 8 unit PEG linker with cleavable properties, commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1]. This compound also serves as a PEG- and Alkyl/ether-based PROTAC linker, enabling its utilization in the synthesis of PROTACs[2]. |
In vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
Molecular Weight | 564.58 |
Formula | C23H40N4O12 |
CAS No. | 1204834-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Azido-PEG8-NHS ester 1204834-00-3 Others Azido-PEG-8-NHS ester Azido PEG8 NHS ester AzidoPEG8NHS ester inhibitor inhibit