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Antofloxacin

Catalog No. T38581 CAS 119354-43-7

Antofloxacin is a well-tolerated, orally active, and broad-spectrum 8-amino-fluoroquinolone compound that exhibits potent antibacterial properties. It demonstrates superior activity against gyrA mutation-positive Helicobacter pylori strains, particularly in strains with mutations in the Asn87 position, when compared to levofloxacin. Additionally, Antofloxacin acts as a weak but reversible inhibitor of CYP1A2 and is clinically used to treat infections caused by various bacterial species.

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Antofloxacin, CAS 119354-43-7

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Administered subcutaneously to mice at doses ranging from 2.5 to 160 mg/kg over a 24-hour period, antofloxacin's penetration ratio for total drug concentrations varied between 1.22 and 1.54, showing no relation to the dosage levels [3]. Additionally, antofloxacin elevates plasma theophylline levels by functioning as a mechanism-based inhibitor of the CYP1A2 enzyme. This inhibition effect on the formation of the three metabolites of theophylline demonstrates a dependency on time, concentration, and the presence of NADPH, indicative of mechanism-based inhibition [2].

Molecular Weight	376.388
Formula	C18H21FN4O4
CAS No.	119354-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. He XJ, et al. Efficacy and Safety of Antofloxacin-Based Triple Therapy for Helicobacter pylori Eradication Failure in China [published online ahead of print, 2021 Feb 8]. Dig Dis Sci. 2021;10.1007/s10620-021-06856-z. 2. Liu L, et al. Modulation of pharmacokinetics of theophylline by antofloxacin, a novel 8-amino-fluoroquinolone, in humans. Acta Pharmacol Sin. 2011;32(10):1285-1293. 3. Zhou YF, et al. In Vivo Pharmacokinetic and Pharmacodynamic Profiles of Antofloxacin against Klebsiella pneumoniae in a Neutropenic Murine Lung Infection Model. Antimicrob Agents Chemother. 2017;61(5):e02691-16. Published 2017 Apr 24.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Antofloxacin 119354-43-7 inhibitor inhibit

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