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Antisauvagine-30 TFA (220673-95-0 free base)

Catalog No. T10338 CAS T10338

Synonyms: Antisauvagine-30 TFA, aSvg-30 TFA

Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.

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Antisauvagine-30 TFA (220673-95-0 free base) Chemical Structure

Antisauvagine-30 TFA (220673-95-0 free base), CAS T10338

Pack Size	Availability	Price/USD	Quantity
1 mg	Inquiry	$ 531.00
5 mg	Inquiry	$ 1,586.00

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Biological Description

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Description	Antisauvagine-30 TFA (aSvg-30 TFA) is a highly selective and competitive antagonist of CRF2 receptor peptidic. It shows a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.
Targets&IC50	CRFR1:150 nM (kd), CRFR2β (mouse):(kd)1.4 nM
In vitro	Antisauvagine-30 prevents stress-enhanced fear conditioning and Mek-1/2-dependent activation of Erk-1/2 and p90Rsk-1. It did not affect the phosphorylation of the PKA regulatory subunit II of stressed mice [1][2].
In vivo	Antisauvagine-30 (i.h. 400 ng/0.5 μl per mouse) selectively prevents the stress-induced enhancement of fear conditioning without affecting the fear conditioning of nonstressed mice[2]. Antisauvagine-30 injected i.c.v. elicits a significant anxiogenic effect [3].

Synonyms	Antisauvagine-30 TFA, aSvg-30 TFA
Molecular Weight	3764.28
Formula	C163H275N48F3O49S
CAS No.	T10338

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Brauns O, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. 2. Sananbenesi F, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci. 2003 Dec 10;23(36):11436-43. 3. Radulovic J, et al. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci. 1999 Jun 15;19(12):5016-25. 4. Klaus Eckart, et al. Action of CRF and its analogs. Current Medicinal Chemistry, 1999, 6, 1035-1053.

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Keywords

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