Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC 50 of 1.7 nM. Alvimopan dihydrate is highly selective for μ-opioid receptor ( Ki =0.47 nM) over κ- and δ-opioid receptors ( Kis =100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 52.00 |
Description | Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC 50 of 1.7 nM. Alvimopan dihydrate is highly selective for μ-opioid receptor ( Ki =0.47 nM) over κ- and δ-opioid receptors ( Kis =100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus [1] [2] [3]. |
In vitro | Alvimopan inhibits the binding of loperamide-stimulated [35 S]GTPγS to membranes containing the cloned human μ-opioid receptor with an IC 50 of 1.7 nM [1]. |
In vivo | Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113 Sn-labelled microspheres produced by morphine in rats [3]. Alvimopan (3 mg/kg; p.o.) has no effect on noxious colorectal distension (CRD)-induced visceromotor behavioural responses (VMR) in conscious rats [3]. |
Molecular Weight | 460.56 |
Formula | C25H36N2O6 |
CAS No. | 170098-38-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Alvimopan dihydrate (LY246736 dihydrate) 170098-38-1 LY246736 LY-246736 Dihydrate LY 246736 Dihydrate Alvimopan LY-246736 LY246736 Dihydrate Alvimopan Dihydrate LY 246736 inhibitor inhibit