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Altenusin

Catalog No. T8895   CAS 31186-12-6

Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.

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Altenusin Chemical Structure
Altenusin, CAS 31186-12-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 389.00
5 mg In stock $ 970.00
10 mg In stock $ 1,289.00
25 mg In stock $ 1,619.00
50 mg In stock $ 2,500.00
100 mg In stock $ 5,200.00
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Purity: 98.97%
Purity: 98.22%
Purity: 97.93%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Targets&IC50 FXR:EC50 : 3.2 ± 0.2 μM
In vitro Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1].
In vivo Administration of 2076A protected mice from high-fat diet (HFD)-induced obesity by reducing the body weight and fat mass by 22.9% and 50.0%, respectively. Administration of 2076A also decreased the blood glucose level from 178.3 ± 12.4 mg/dl to 116.2 ± 4.1 mg/dl and the serum insulin level from 1.4 ± 0.6 ng/dl to 0.4 ± 0.1 ng/dl[1].
Molecular Weight 290.27
Formula C15H14O6
CAS No. 31186-12-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (172.25 mM)

TargetMolReferences and Literature

1. Zheng Z, Zhao Z, Li S, et al. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. Mol Pharmacol. 2017;92(4):425-436. doi:10.1124/mol.117.108829

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library Natural Product Library for HTS Polyphenolic Natural Product Library Bioactive Compound Library Metabolism Compound Library RO5 Drug-like Natural Product Library Lipid Metabolism Compound Library Anti-Metabolism Disease Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max

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Keywords

Altenusin 31186-12-6 Metabolism FXR inhibit Alutenusin Inhibitor inhibitor

 

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