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Altenusin

Catalog No. T8895 CAS 31186-12-6

Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.

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Altenusin, CAS 31186-12-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Targets&IC50	FXR:EC50 : 3.2 ± 0.2 μM
In vitro	Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1].
In vivo	Administration of 2076A protected mice from high-fat diet (HFD)-induced obesity by reducing the body weight and fat mass by 22.9% and 50.0%, respectively. Administration of 2076A also decreased the blood glucose level from 178.3 ± 12.4 mg/dl to 116.2 ± 4.1 mg/dl and the serum insulin level from 1.4 ± 0.6 ng/dl to 0.4 ± 0.1 ng/dl[1].

Molecular Weight	290.271
Formula	C15H14O6
CAS No.	31186-12-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zheng Z, Zhao Z, Li S, et al. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. Mol Pharmacol. 2017;92(4):425-436. doi:10.1124/mol.117.108829

Related compound libraries

This product is contained In the following compound libraries：

Anti-Metabolism Disease Compound Library Rare Natural Compound Library Nuclear Receptor Compound Library Bioactive Compound Library

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Keywords

Altenusin 31186-12-6 代谢 FXR inhibit Alutenusin Inhibitor inhibitor

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