Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
Description | Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM. |
Targets&IC50 | FXR:EC50 : 3.2 ± 0.2 μM |
In vitro | Treatment of primary mouse hepatocytes with altenusin inhibited oleic acid–induced steatosis in vitro [1]. |
In vivo | Administration of 2076A protected mice from high-fat diet (HFD)-induced obesity by reducing the body weight and fat mass by 22.9% and 50.0%, respectively. Administration of 2076A also decreased the blood glucose level from 178.3 ± 12.4 mg/dl to 116.2 ± 4.1 mg/dl and the serum insulin level from 1.4 ± 0.6 ng/dl to 0.4 ± 0.1 ng/dl[1]. |
Molecular Weight | 290.271 |
Formula | C15H14O6 |
CAS No. | 31186-12-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Altenusin 31186-12-6 代谢 FXR inhibit Alutenusin Inhibitor inhibitor