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Alendronate sodium hydrate

Catalog No. T6373   CAS 121268-17-5
Synonyms: G-704650, Alendronate, MK 217, Alendronate sodium trihydrate, G-704650 Adronat, Fosamax

Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.

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Alendronate sodium hydrate Chemical Structure
Alendronate sodium hydrate, CAS 121268-17-5
Pack Size Availability Price/USD Quantity
50 mg In stock $ 40.00
100 mg In stock $ 48.00
200 mg In stock $ 54.00
500 mg In stock $ 85.00
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Purity: 99.78%
Purity: 99.59%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.
Targets&IC50 farnesyl diphosphate synthase:460 nM.
Kinase Assay Rat liver cytosol is prepared from a separate piece of liver from rat. Assays are carried out in a total volume of 0.1 mL containing 10 mg of cytosolic protein, and components according to Rilling. All reaction components (except IPP) are mixed and kept on ice for 15 min. Reactions are initiated by the addition of [14C]IPP and incubation at 37°C. Reactions are stopped after 5 min by addition of 0.4 mL MeOH/HCl (4/1, by vol.) and the samples are incubated a further 15 min to hydrolyze the allylic pyrophosphates to petroleum ether-extractable products. Following addition of 0.5 mL water and 1 mL petroleum ether, 50% of the upper (petroleum ether-extractable) phase is taken for liquid scintillation analysis. Preliminary experiments indicated that the reaction is linear with time and protein under these conditions, and no more than 10% of the substrate is consumed.
Synonyms G-704650, Alendronate, MK 217, Alendronate sodium trihydrate, G-704650 Adronat, Fosamax
Molecular Weight 325.12
Formula C4H12NO7P2·3H2O·Na
CAS No. 121268-17-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

TargetMolReferences and Literature

1. Fisher JE, et al. Proc Natl Acad Sci U S A, 1999, 96(1), 133-138. 2. Bergstrom JD, et al. Arch Biochem Biophys, 2000, 373(1), 231-241. 3. Keller RK, et al. Biochem Biophys Res Commun, 1999, 266(2), 560-563. 4. Elliott SN, et al. Life Sci, 1998, 62(1), 77-91. 5. Stearns ME, et al. Invasion Metastasis, 1996, 16(3), 116-131.

Related compound libraries

This product is contained In the following compound libraries:
Pediatric Drug Library Metabolism Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Toxic Compound Library Inhibitor Library Bioactive Compounds Library Max NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library Orally Active Compound Library

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Keywords

Alendronate sodium hydrate 121268-17-5 Metabolism Transferase MK-217 G-704650 Alendronate sodium Trihydrate Alendronate inhibit Alendronate sodium MK 217 Alendronate sodium trihydrate MK217 Inhibitor G 704650 G-704650 Adronat Fosamax Alendronate sodium Hydrate G704650 inhibitor

 

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