store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mL * 10 mM (in DMSO) | In stock | $ 457.00 |
Description | Aldumastat (GLPG1972) is a highly potent, specific and orally active inhibitor of ADAMTS-5.Aldumastat is used for the study of osteoarthritis of the knee. |
Targets&IC50 | ADAMTS-5:19 nM, MMP2:1158 nM, ADAMTS-4:156 nM, MMP14:>3198 nM |
In vivo | Aldumastat (GLPG1972;1mg/kg i.v./5mg/kg p.o.) displayed favorable pharmacokinetic profiles in mice, rats, and dogs, with oral bioavailability of 25%, 58%, and 97%, respectively.[1]. |
Synonyms | GLPG1972, S201086, G504572 |
Molecular Weight | 406.43 |
Formula | C20H24F2N4O3 |
CAS No. | 1957278-93-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (222.34 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Aldumastat 1957278-93-1 Others GLPG1972 S201086 G504572 inhibitor inhibit