Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 35.00 | |
10 mg | In stock | $ 56.00 | |
25 mg | In stock | $ 71.00 | |
50 mg | In stock | $ 89.00 | |
100 mg | In stock | $ 158.00 | |
200 mg | In stock | $ 205.00 | |
500 mg | In stock | $ 466.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 62.00 |
Description | Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). |
Kinase Assay | Lipid kinase activity : IC50 values are measured using a standard lipid kinase activity with PI as a substrate. (i)100 μM cold ATP is used instead of 10 μM, (ii) the DMSO concentration is 1%, and (iii) [γ-33P]ATP is used instead of [γ-32P]ATP. The TLC plates are quantified using a phosphorimager screen. The reported IC50 values are determined by non-linear regression analysis on the basis of at least three independent experiments repeated across multiple preparations of recombinant protein. |
Cell Research | Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5 μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96-well plates at final volume of 0.2 mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]-thymidine per well at 16 h before the end of the incubation. The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillation counter. |
Synonyms | Alda 1 |
Molecular Weight | 324.16 |
Formula | C15H11Cl2NO3 |
CAS No. | 349438-38-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.4 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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Alda-1 349438-38-6 Apoptosis Metabolism Dehydrogenase inhibit Aldehyde Dehydrogenase (ALDH) Inhibitor Alda1 Alda 1 inhibitor