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Alda-1

Catalog No. T2662   CAS 349438-38-6
Synonyms: Alda 1

Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).

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Alda-1 Chemical Structure
Alda-1, CAS 349438-38-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 35.00
10 mg In stock $ 56.00
25 mg In stock $ 71.00
50 mg In stock $ 89.00
100 mg In stock $ 158.00
200 mg In stock $ 205.00
500 mg In stock $ 466.00
1 mL * 10 mM (in DMSO) In stock $ 62.00
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Purity: 100%
Purity: 99.93%
Purity: 99.71%
Purity: 99.52%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
Kinase Assay Lipid kinase activity : IC50 values are measured using a standard lipid kinase activity with PI as a substrate. (i)100 μM cold ATP is used instead of 10 μM, (ii) the DMSO concentration is 1%, and (iii) [γ-33P]ATP is used instead of [γ-32P]ATP. The TLC plates are quantified using a phosphorimager screen. The reported IC50 values are determined by non-linear regression analysis on the basis of at least three independent experiments repeated across multiple preparations of recombinant protein.
Cell Research Spleen cells (4×106 cells/mL) are stimulated by optimal concentrations of concanavalin A (Con A; 2.5 μg/mL and 0.6 μg/mL) and lipopolysaccharide (LPS, 5 μg/mL) and are incubated in 96-well plates at final volume of 0.2 mL for 72 h. Cell proliferation is determined by adding 0.5 μCi of [3H]-thymidine per well at 16 h before the end of the incubation. The cultures are harvested with an automatic cell harvester, and [3H] thymidine incorporation is assessed using a liquid scintillation counter.
Synonyms Alda 1
Molecular Weight 324.16
Formula C15H11Cl2NO3
CAS No. 349438-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.4 mg/mL(100 mM)

TargetMolReferences and Literature

1. Stachowicz A, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci. 2. Stachowicz A, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016 Jan;51:144-53. 3. Ikeda T, et al. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e20128844. 4. Gomes KM, et al. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015 Jan 20;179:129-138.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Anti-Cancer Metabolism Compound Library Metabolism Compound Library Apoptosis Compound Library Glutamine Metabolism Compound Library Bioactive Compound Library Mitochondria-Targeted Compound Library

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Keywords

Alda-1 349438-38-6 Apoptosis Metabolism Dehydrogenase inhibit Aldehyde Dehydrogenase (ALDH) Inhibitor Alda1 Alda 1 inhibitor

 

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