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Adenosine Kinase Inhibitor (hydrate)

Catalog No. T22554 CAS T22554

Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associated with the systemic administration of adenosine receptor agonists (IC50: 1.7 nM in cell-free assays).

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Adenosine Kinase Inhibitor (hydrate) Chemical Structure

Adenosine Kinase Inhibitor (hydrate), CAS T22554

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 80.00
5 mg	Inquiry	$ 313.00
10 mg	Inquiry	$ 390.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associated with the systemic administration of adenosine receptor agonists (IC50: 1.7 nM in cell-free assays).
In vitro	Adenosine Kinase Inhibitor was found to be a potent non-nucleoside adenosine kinase inhibitor with several folds of magnitude selectivity over other sites of adenosine interaction. Adenosine Kinase Inhibitor was 1300- to 7700-fold selective for adenosine kinase compared with other neurotransmitters and peptide receptors, neurotransmitter/nucleoside reuptake sites, and enzymes. Adenosine Kinase Inhibitor was equipped in inhibiting native human adenosine kinase, human recombinant isoforms, as well as adenosine kinase from dog, rat, monkey, and mouse brain [1].
In vivo	Adenosine Kinase Inhibitor was orally active and efficacious in reducing acute somatic nociception in the mouse hot-plate assay. Adenosine Kinase Inhibitor could dose-dependently reduce nociception in the phenyl-p-quinone-induced abdominal constriction assay. The antinociceptive effects of Adenosine Kinase Inhibitor in the hotplate assay were stopped by the nonselective adenosine receptor antagonist theophylline, but not by a peripherally selective adenosine receptor antagonist [1].

Molecular Weight	470.5
Formula	C22H19BrN6O·0.4H2O
CAS No.	T22554

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≤30mg/ml

References and Literature

1. Buang Y. Dietary adenine alleviates fatty liver induced by orotic acid. Indo. J. Chem. 2010; 10 (3): 363 - 369. 2. Módis K, Ger D, Nagy N, Szoleczky P, Tóth ZD and Szabó C. Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. Br J Pharmacol. 2009 Nov; 158(6): 1565–8.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Adenosine Kinase Inhibitor (hydrate) T22554 Others Adenosine Kinase Inhibitor inhibitor inhibit

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