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ATP-polyamine-biotin

Catalog No. T17454   CAS 1800401-93-7

ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.

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ATP-polyamine-biotin Chemical Structure
ATP-polyamine-biotin, CAS 1800401-93-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. APB is cell-permeable and nontoxic at low mM concentrations, with cell penetration and labeling dependent on the polyamine linker.
Molecular Weight 945.86
Formula C32H58N11O14P3S
CAS No. 1800401-93-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 6 mg/mL (6.34 mM), Sonication and heating are recommended.

TargetMolReferences and Literature

1. Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9618-21.

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Keywords

ATP-polyamine-biotin 1800401-93-7 Others ATP polyamine biotin ATPpolyaminebiotin inhibitor inhibit

 

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