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ADU-S100

Catalog No. T10252L3 CAS 1638241-89-0

Synonyms: ML RR-S2 CDA, MIW815

ADU-S100 is an activator of stimulator of interferon genes (STING).

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ADU-S100, CAS 1638241-89-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	Inquiry
50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ADU-S100 is an activator of stimulator of interferon genes (STING).
In vitro	ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP[1].
In vivo	A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].

Synonyms	ML RR-S2 CDA, MIW815
Molecular Weight	690.54
Formula	C20H24N10O10P2S2
CAS No.	1638241-89-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (72.41 mM), Sonification is recommended.

DMSO: 2 mg/mL (2.90 mM), Sonification is recommended.

References and Literature

1. Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30.

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ADU-S100 1638241-89-0 Others ADUS100 ADU S100 MIW 815 ADU-S-100 ADU-S 100 MIW-815 ML RR-S2 CDA MIW815 inhibitor inhibit

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