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AC260584

Catalog No. T14092 CAS 560083-42-3

AC260584 is an M1 muscarinic receptor allosteric agonist (pEC50: 7.6).

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AC260584, CAS 560083-42-3

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 327.00
25 mg	6-8 weeks	$ 1,140.00
50 mg	6-8 weeks	$ 1,490.00
100 mg	6-8 weeks	$ 1,990.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 270.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC260584 is an M1 muscarinic receptor allosteric agonist (pEC50: 7.6).
Targets&IC50	M1:（pEC50）7.6
In vitro	AC260584 is identified as a potent (pEC50=7.6-7.7) and efficacious (90-98% of carbachol) agonist for the muscarinic M1 receptor, exhibiting significant functional selectivity over the M2, M3, M4, and M5 subtypes of muscarinic receptors. This selectivity profile of AC260584 is consistent across native tissues expressing mAChRs and recombinant systems.
In vivo	In rodent studies, AC260584 has been shown to activate the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the hippocampus, prefrontal cortex, and perirhinal cortex. This activation is contingent upon the activation of muscarinic M1 receptors, as evidenced by its absence in M1 receptor knockout mice. Furthermore, AC260584 enhances cognitive performance in mice, as demonstrated in the novel object recognition test, with this effect being inhibited by the muscarinic receptor antagonist pirenzepine. Additionally, AC260584 has been noted for its oral bioavailability in rodents. At doses of 3 and 10 mg/kg, AC260584 significantly boosts dopamine release in the medial prefrontal cortex and hippocampus, while only the 10 mg/kg dose notably increases acetylcholine release in these areas.

Molecular Weight	348.45
Formula	C20H29FN2O2
CAS No.	560083-42-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (143.49 mM)

References and Literature

1. Bradley SR, et al. AC260584, an orally bioavailable M(1) muscarinic receptor allosteric agonist, improves cognitive performance in an animal model. Neuropharmacology. 2010 Feb;58(2):365-73. 2. Li Z, et al. AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. Eur J Pharmacol. 2007 Oct 31;572(2-3):129-37.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC260584 560083-42-3 Others AC 260584 AC-260584 inhibitor inhibit

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