Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules that are derived from other metabolic pathways.
Description | 5-A-RU (5-Amino-6-(D-ribitylamino)uracil), a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules that are derived from other metabolic pathways. |
In vitro | 5-A-RU presents in diverse bacteria and yeast as well as plants. 5-A-RU plays an important role in MAIT cell activation, MR1 could not be refolded efficiently with 5-ARU alone. 5-A-RU is a precursor for MAIT cell ligand [2]. 5-A-RU can react extemporaneously with glyoxal and methylglyoxal to generate pyrimidine adducts that activate mouse MAIT cells from STg (iVa19) and DTg (iVa19Vb6) animals [3]. |
In vivo | 5-A-RU (100 nM; i.p.; 18 hours) and methylglyoxal (MeG) are mixed extemporaneously, MAIT cells are activated in iVa19 Cα-/- Tg mice (generated on the C57BL/6 background) [3]. |
Synonyms | 5-Amino-6-(D-ribitylamino)uracil |
Molecular Weight | 276.249 |
Formula | C9H16N4O6 |
CAS No. | 17014-74-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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5-A-RU 17014-74-3 Others 5 A RU 5-Amino-6-(D-ribitylamino)uracil 5ARU inhibitor inhibit