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5α-Pregnane-3β,6α-diol-20-one
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Catalog No. T13518Cas No. 21853-11-2
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.
5α-Pregnane-3β,6α-diol-20-one
🥰Excellent
Purity: 99.95%
Catalog No. T13518Cas No. 21853-11-2
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $45 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $169 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $476 | In Stock | |
| 100 mg | $668 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $108 | In Stock |
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Purity:99.95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions. |
| In vitro | Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts [1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather dependent on 3β-HSD activity [2]. |
| Molecular Weight | 334.49 |
| Formula | C21H34O3 |
| Cas No. | 21853-11-2 |
| Smiles | [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](O)[C@@]2([H])C[C@@H](O)CC[C@]12C |
| Relative Density. | 1.117 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (298.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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