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4-Methoxy 17β-Estradiol

Catalog No. T9456 CAS 26788-23-8

4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.

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4-Methoxy 17β-Estradiol Chemical Structure

4-Methoxy 17β-Estradiol, CAS 26788-23-8

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Description	4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
In vitro	4-Methoxy-17-estradiol treatment significantly decreased cell growth and increased mitotic index. Elevation of ROS and SOD activity, with a concomitant decrease in the intracellular GSH/GSSG ratio, was also detected in 4-Methoxy-17-estradiol-treated cells. Quantitative comet assay showed increased oxidative DNA damage in the 4-Methoxy-17-estradiol-treated H1355 cells, which could be significantly reduced by the anti-oxidant N-acetylcysteine (NAC)[1].
In vivo	4-Methoxy-17-estradiol had much weaker estrogenic activity and have similar lipid-modulating effects compared to 4-hydroxyestradiol in ovariectomized female rats[3].

Molecular Weight	302.41
Formula	C19H26O3
CAS No.	26788-23-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cheng Y, et al. 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells. Toxicol Appl Pharmacol. 2007 May 1;220(3):271-7. 2. Camargo MC, et al. Urinary estrogen metabolites and gastric cancer risk among postmenopausal women. Cancer Rep (Hoboken). 2021 Nov 11:e1574. 3. Wang P, Zhu BT. Unique effect of 4-hydroxyestradiol and its methylation metabolites on lipid and cholesterol profiles in ovariectomized female rats. Eur J Pharmacol. 2017 Apr 5;800:107-117.

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Keywords

4-Methoxy 17β-Estradiol 26788-23-8 Others 4Methoxy 17βEstradiol 4-Methoxy 17beta-Estradiol 4-Methoxy 17b-Estradiol 4 Methoxy 17β Estradiol inhibitor inhibit

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