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3,4,5-Trihydroxycinnamic acid decyl ester

Catalog No. T39189 CAS 1770778-45-4

3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties. Additionally, this compound acts as a pancreatic lipase inhibitor, with an EC 50 of around 0.9 μM.

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3,4,5-Trihydroxycinnamic acid decyl ester Chemical Structure

3,4,5-Trihydroxycinnamic acid decyl ester, CAS 1770778-45-4

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Description	3,4,5-Trihydroxycinnamic acid decyl ester, an effective inhibitor of lipid absorption and accumulation, exhibits anti-obesity properties. Additionally, this compound acts as a pancreatic lipase inhibitor, with an EC 50 of around 0.9 μM.
Targets&IC50	Pancreatic lipase:0.9 μM (EC50)
In vitro	3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) effectively inhibits pancreatic lipase activity by approximately 92% in vitro[1]. This compound demonstrates dose-dependent inhibition of pancreatic lipase, ranging between 0.1-40 μM, with an EC 50 value of around 0.9 μM[1]. Additionally, it prevents lipid accumulation during 3T3-L1 cell differentiation, highlighting its potential for influencing lipid metabolism[1].
In vivo	3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) effectively suppresses the elevation of blood triglyceride (TG) levels in 6-week-old male ddY mice administered corn oil orally[1]. The compound was administered orally at dosages of 30 mg/kg and 150 mg/kg, resulting in a dose-dependent reduction in plasma TG levels[1].

Molecular Weight	336.428
Formula	C19H28O5
CAS No.	1770778-45-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.

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Keywords

3,4,5-Trihydroxycinnamic acid decyl ester 1770778-45-4 3,4,5 Trihydroxycinnamic acid decyl ester 3,4,5Trihydroxycinnamic acid decyl ester inhibitor inhibit

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