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25,26-Dihydroxyvitamin D3

Catalog No. T13490 CAS 29261-12-9

Synonyms: 25,26-Dihydroxycholecalciferol

25,26-Dihydroxyvitamin D3 is a metabolite of vitamin D3 with intestinal calcium transport activity.

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25,26-Dihydroxyvitamin D3 Chemical Structure

25,26-Dihydroxyvitamin D3, CAS 29261-12-9

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Biological Description

Chemical Properties

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Description

25,26-Dihydroxyvitamin D3 is a metabolite of vitamin D3 with intestinal calcium transport activity.

In vitro

24,25 and 25,26 diOHD3 (0.125-0.250 mug) were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The 'bone calcium mobilization' of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3 [2].

Synonyms	25,26-Dihydroxycholecalciferol
Molecular Weight	416.64
Formula	C27H44O3
CAS No.	29261-12-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. DeLuca HF, et al. 25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. Biochemistry. 1970 Nov 24;9(24):4776-80. 2. Miravet L, et al. The biological activity of synthetic 25,26-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in vitamin D-deficient rats. Calcif Tissue Res. 1976 Dec 2;21(3):145-52. 3. Fraher LJ, et al. Determination of circulating 25,26-dihydroxycholecalciferol in man by radioimmunoassay. Clin Sci (Lond). 1980 Oct;59(4):257-63.

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Keywords

25,26-Dihydroxyvitamin D3 29261-12-9 Others 25,26-Dihydroxycholecalciferol 25,26 Dihydroxyvitamin D3 25,26-Dihydroxyvitamin D-3 25,26Dihydroxyvitamin D3 inhibitor inhibit

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