Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 455.00 | |
50 μg | 35 days | $ 793.00 | |
100 μg | 35 days | $ 1,530.00 |
Description | Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation. |
Molecular Weight | 360.494 |
Formula | C22H32O4 |
CAS No. | 871826-47-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Miscible
PBS (pH 7.2): 0.5 mg/mL
DMSO: Miscible
0.1 M Na2CO3: 1 mg/mL
Ethanol: Miscible
You can also refer to dose conversion for different animals. More
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10(S),17(S)-DiHDHA 871826-47-0 10,17DiHDHA 10(S),17(S) DiHDHA 10(S),17(S)DiHDHA inhibitor inhibit