This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
1,1,1-Trifluoroethyl-PEG4-alcohol
Catalog No. T13985 CAS
1807512-41-9
1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of protein degrader molecules, known as PROTACs[1].
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1,1,1-Trifluoroethyl-PEG4-alcohol, CAS 1807512-41-9
1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of protein degrader molecules, known as PROTACs[1].
In vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Molecular Weight
276.25
Formula
C10H19F3O5
CAS No.
1807512-41-9
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.