Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 30.00 | |
5 mg | 5 days | $ 45.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 55.00 |
Description | (Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
In vitro | (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1]. |
In vivo | (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. |
Synonyms | ADH-503 free base |
Molecular Weight | 421.49 |
Formula | C22H15NO4S2 |
CAS No. | 2055362-72-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (9.49 mM), Sonification and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(Z)-Leukadherin-1 2055362-72-4 Immunology/Inflammation Complement System orally macrophages ADH-503 repolarization ADH 503 ADH-503 free base dendritic allosteric CD11b tumorassociated ADH503 (Z)Leukadherin1 Inhibitor (Z) Leukadherin 1 tumor-infiltrating inhibit Leukadherin-1 immunosuppressive inhibitor