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(R)-Lansoprazole

Catalog No. T1021 CAS 138530-94-6

Synonyms: R-(+)-Lansoprazole, TAK 390, Dexlansoprazole, T 168390

Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)

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(R)-Lansoprazole, CAS 138530-94-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship. [1] Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production. [2]

Synonyms	R-(+)-Lansoprazole, TAK 390, Dexlansoprazole, T 168390
Molecular Weight	369.36
Formula	C16H14F3N3O2S
CAS No.	138530-94-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 74 mg/mL (200.34 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Metz DC, et al. Aliment Pharmacol Ther, 2009, 29(9), 928-937. 2. Emerson CR, et al. Clin Ther, 2010, 32(9), 1578-1596. 3. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches[J]. RSC Advances. 2018 Jan 8(10): 5286-5297.

Citations

1. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches. RSC Advances. 2018 Jan 8(10): 5286-5297.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(R)-Lansoprazole 138530-94-6 Membrane transporter/Ion channel Proton pump Inhibitor Proton Pump R-(+)-Lansoprazole TAK 390 Dexlansoprazole inhibit (R) Lansoprazole T 168390 (R)Lansoprazole inhibitor

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