Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Description | Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) |
In vitro | Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship. [1] Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production. [2] |
Synonyms | R-(+)-Lansoprazole, TAK 390, Dexlansoprazole, T 168390 |
Molecular Weight | 369.36 |
Formula | C16H14F3N3O2S |
CAS No. | 138530-94-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 74 mg/mL (200.34 mM)
Ethanol: <1 mg/mL
H2O: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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(R)-Lansoprazole 138530-94-6 Membrane transporter/Ion channel Proton pump Inhibitor Proton Pump R-(+)-Lansoprazole TAK 390 Dexlansoprazole inhibit (R) Lansoprazole T 168390 (R)Lansoprazole inhibitor