Shopping Cart
- Remove All
- Your shopping cart is currently empty
α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | Backorder | |
5 mg | $363 | Backorder | |
10 mg | $579 | Backorder | |
25 mg | $891 | Backorder |
Description | α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors. |
Targets&IC50 | α3β2:7.3 μM, α3β4:4.2 μM, α3α5β2:7.2 μM |
In vitro | α-Conotoxin Vc1.1 TFA is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2(IC50=7.2 μM), α3β2(IC50=7.3 μM) and α3β4(IC50=4.2 μM) and has less inhibitory effect on other nAChR subtypes. [1] |
In vivo | Once-daily intramuscular injection of 0.18-18 μg/μL α-Conotoxin Vc1.1 TFA for 7 consecutive days in male Sprague-Dawley rats suppressed pain behavior and accelerated functional recovery of damaged neurons in a sciatic nerve chronic compression injury (CCI) model. [2] |
Molecular Weight | 1925.03 |
Formula | C73H108F3N23O27S4 |
Smiles | [H]NCC(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC(O)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N[C@H](C(N[C@]([H])(C(N[C@@H](CS)C(N)=O)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O.O=C(O)C(F)(F)F |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (41.64 mM.), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.