Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact Us
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

α-Conotoxin Vc1.1 TFA

😃Good
Catalog No. T73894

α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.

α-Conotoxin Vc1.1 TFA

α-Conotoxin Vc1.1 TFA

😃Good
Purity: 97.57%
Catalog No. T73894
α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Pack SizePriceAvailabilityQuantity
1 mg$143 Backorder
5 mg$363 Backorder
10 mg$579 Backorder
25 mg$891 Backorder
Add to Cart
Add to Quotation
Bulk & Custom
Questions
View More

Related Compound Libraries of "α-Conotoxin Vc1.1 TFA"

Select Batch
Purity:97.57%
Contact us for more batch information
Resource Download
COA HPLC MS
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Targets&IC50
α3β2:7.3 μM, α3β4:4.2 μM, α3α5β2:7.2 μM
In vitro
α-Conotoxin Vc1.1 TFA is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2(IC50=7.2 μM), α3β2(IC50=7.3 μM) and α3β4(IC50=4.2 μM) and has less inhibitory effect on other nAChR subtypes. [1]
In vivo
Once-daily intramuscular injection of 0.18-18 μg/μL α-Conotoxin Vc1.1 TFA for 7 consecutive days in male Sprague-Dawley rats suppressed pain behavior and accelerated functional recovery of damaged neurons in a sciatic nerve chronic compression injury (CCI) model. [2]
Chemical Properties
Molecular Weight1925.03
FormulaC73H108F3N23O27S4
Smiles[H]NCC(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC(O)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N[C@H](C(N[C@]([H])(C(N[C@@H](CS)C(N)=O)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O.O=C(O)C(F)(F)F
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (41.64 mM.), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.5195 mL2.5974 mL5.1947 mL25.9736 mL
5 mM0.1039 mL0.5195 mL1.0389 mL5.1947 mL
10 mM0.0519 mL0.2597 mL0.5195 mL2.5974 mL
20 mM0.0260 mL0.1299 mL0.2597 mL1.2987 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

nAChR
Related Tags: buy α-Conotoxin Vc1.1 TFA | purchase α-Conotoxin Vc1.1 TFA | α-Conotoxin Vc1.1 TFA cost | order α-Conotoxin Vc1.1 TFA | α-Conotoxin Vc1.1 TFA chemical structure | α-Conotoxin Vc1.1 TFA in vivo | α-Conotoxin Vc1.1 TFA in vitro | α-Conotoxin Vc1.1 TFA formula | α-Conotoxin Vc1.1 TFA molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.