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α-Conotoxin Vc1.1 TFA

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Catalog No. T73894

α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.

α-Conotoxin Vc1.1 TFA

α-Conotoxin Vc1.1 TFA

😃Good
Purity: 97.57%
Catalog No. T73894
α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Pack SizePriceAvailabilityQuantity
1 mg$143 Backorder
5 mg$363 Backorder
10 mg$579 Backorder
25 mg$891 Backorder
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Purity:97.57%
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Product Introduction

Bioactivity
Description
α-Conotoxin Vc1.1 TFA is a peptide isolated from Conus victoriae and a selective nAChR antagonist that inhibits α3α5β2, α3β2 and α3β4, reversing mechanical allodynia in neuropathic pain models and can be used to study neuropathic chronic pain. α-Conotoxin Vc1.1 TFA inhibits human dorsal root ganglion nerve excitability and mouse colon nociception via GABA(B) receptors.
Targets&IC50
α3β2:7.3 μM, α3β4:4.2 μM, α3α5β2:7.2 μM
In vitro
α-Conotoxin Vc1.1 TFA is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2(IC50=7.2 μM), α3β2(IC50=7.3 μM) and α3β4(IC50=4.2 μM) and has less inhibitory effect on other nAChR subtypes. [1]
In vivo
Once-daily intramuscular injection of 0.18-18 μg/μL α-Conotoxin Vc1.1 TFA for 7 consecutive days in male Sprague-Dawley rats suppressed pain behavior and accelerated functional recovery of damaged neurons in a sciatic nerve chronic compression injury (CCI) model. [2]
Chemical Properties
Molecular Weight1925.03
FormulaC73H108F3N23O27S4
Smiles[H]NCC(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC(O)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CN=CN3)C(N4CCC[C@H]4C(N[C@H](C(N[C@]([H])(C(N[C@@H](CS)C(N)=O)=O)[C@@H](C)CC)=O)CCC(O)=O)=O)=O)=O)=O)=O)CC(N)=O)=O)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O.O=C(O)C(F)(F)F
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (41.64 mM.), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.5195 mL2.5974 mL5.1947 mL25.9736 mL
5 mM0.1039 mL0.5195 mL1.0389 mL5.1947 mL
10 mM0.0519 mL0.2597 mL0.5195 mL2.5974 mL
20 mM0.0260 mL0.1299 mL0.2597 mL1.2987 mL

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Keywords

nAChR
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