Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HAMI 3379 is a potent and selective antagonist of the Cysteinyl leukotriene (CysLT2) receptor. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury. It also attenuates microglia-related inflammation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | HAMI 3379 is a potent and selective antagonist of the Cysteinyl leukotriene (CysLT2) receptor. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury. It also attenuates microglia-related inflammation. |
In vitro | HAMI 3379 shows very low potency on a recombinant CysLT1 receptor cell line (IC50>10000 nM). HAMI 3379 antagonizes leukotriene D4- (LTD4-) and leukotriene C4- (LTC4-) induced intracellular calcium mobilization (IC50: 3.8 nM and 4.4 nM, respectively), in a CysLT2 receptor reporter cell line[1]. |
In vivo | HAMI 3379 (infused into the aortic cannula at a rate of 1% of the total flow rate; 0.01, 0.1, 1 μM; 20 min) concentration-dependently inhibits and reverses the LTC4-induced perfusion pressure increase and contractility decrease[1]. HAMI 3379 (ip; 0.025-0.4 mg/kg; 24 hours) decreases the acute brain injury 24 hours after middle cerebral artery occlusion (MCAO) with effective doses of 0.1-0.4 mg/kg and a therapeutic window of ~1 hour. It reduces neurological deficits and reduces infarct volume, brain edema, and neuronal loss and degeneration 24 and 72 hours after MCAO[2]. |
Synonyms | HAMI 3379 |
Molecular Weight | 595.72 |
Formula | C34H45NO8 |
CAS No. | 712313-35-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(Rac)-HAMI 3379 712313-35-4 Others (Rac) HAMI 3379 HAMI3379 HAMI-3379 HAMI 3379 (Rac)HAMI 3379 inhibitor inhibit