Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(RS)-PPG is a potent and selective group III mGluRs agonist(EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively),with neuroprotective and anticonvulsive activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | (RS)-PPG is a potent and selective group III mGluRs agonist(EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively),with neuroprotective and anticonvulsive activity. |
Targets&IC50 | mGluR7b (human):185 μM (EC50), mGluR4a (human):5.2 μM (EC50), mGluR8a (human):0.2 μM (EC50), mGluR6 (human):4.7 μM (EC50) |
In vitro | Activation of neurons in group III mGluRs by (RS)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2]. |
Molecular Weight | 231.14 |
Formula | C8H10NO5P |
CAS No. | 120667-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(RS)-PPG 120667-15-4 Others (RS)PPG (RS) PPG inhibitor inhibit