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(±)19(20)-EDP Ethanolamide

Catalog No. T35468 CAS 2123485-34-5

(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. (±)19(20)-EDP ethanolamide (25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It decreases the production of IL-6 and increases the production of IL-10 when used at concentrations ranging from 2.5 to 10 μM in BV-2 microglia stimulated by LPS and decreases LPS-induced cytotoxicity when used at concentrations ranging from 5 to 10 μM. It also decreases nitrite production when used at a concentration of 7.5 μM, an effect that can be partially reversed by the CB2 receptor antagonist AM630 and the PPARγ antagonist GW 9662 . (±)19(20)-EDP ethanolamide induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM) and reduces tube formation by human microvascular endothelial cells (HMVECs) in a Matrigel assay.

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(±)19(20)-EDP Ethanolamide Chemical Structure

(±)19(20)-EDP Ethanolamide, CAS 2123485-34-5

Pack Size	Availability	Price/USD
25 μg	35 days	$ 98.00
50 μg	35 days	$ 195.00
100 μg	35 days	$ 363.00
500 μg	35 days	$ 1,600.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	387.564
Formula	C24H37NO3
CAS No.	2123485-34-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 50 mg/mL

Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL

DMSO: 50 mg/mL

Ethanol: 50 mg/mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(±)19(20)-EDP Ethanolamide 2123485-34-5 19(20)-EDP Ethanolamide (±)19(20)EDP Ethanolamide (±)19(20) EDP Ethanolamide inhibitor inhibit

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