Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 365.00 | |
50 μg | 35 days | $ 695.00 | |
100 μg | 35 days | $ 1,310.00 |
Description | Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity. |
Molecular Weight | 320.473 |
Formula | C20H32O3 |
CAS No. | 128914-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Miscible
DMSO: Miscible
Ethanol: Miscible
PBS (pH 7.2): 0.8 mg/mL
0.1 M Na2CO3: 2 mg/mL
You can also refer to dose conversion for different animals. More
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(±)16-HETE 128914-46-5 (±)16HETE (±)16 HETE 16-HETE inhibitor inhibit