Compound Libraries Endoplasmic Reticulum Stress Compound Library

Endoplasmic Reticulum Stress Compound Library

Catalog No. L9700
  Library Compound List   Excel SDF

The endoplasmic reticulum (ER) is the cellular organelle that is critical for protein folding and secretion, calcium homeostasis, and lipid biosynthesis. The ER is the site of multiple post-translational modifications such as glycosylation and disulfide bond formation. It is also the organelle in which proteins are folded into their proper conformation and in which multi-subunit proteins are assembled. Endoplasmic reticulum stress (ER stress), such as unfolded protein response (UPR) and ER overload response (EOR), occurs when proteins are not properly folded or conformed (misfolded protein) or homeostasis cannot be maintained such as disturbances in redox regulation, calcium regulation, glucose deprivation, and viral infection. As a result, ER-localized chaperones such as glucose-regulated proteins (GRP78, GRP94, etc.) are induced, protein synthesis is slowed down, and a protein degrading system is initiated. However, excessive and prolonged stresses lead cells to caspase-12 mediated apoptosis.

ER stress occurs not only in both normal and pathophysiological conditions, but has also been implicated in multiple disorders such as cancers, type 2 diabetes, ischemia, viral infection, and neurodegenerative disorders. ER stress can also be induced by hypoxia. This has implications for solid tumors which usually exhibit hypoxia in their cores. Insulin resistance is also associated with ER stress and the treatment of type 2 diabetic mice with chemical chaperones which assist protein folding in the ER restored insulin sensitivity. It has also been proposed that agents that cause ER stress can be used directly as chemotherapeutic agents.

TargetMol’s Endoplasmic Reticulum Stress Compound Library collects 155 ER stress related compounds, targeting different targets in ER stress signaling pathway such as PERK, IRE1, ATF6, GRP78, etc. It is an effective tool for research in endoplasmic reticulum stress and related diseases.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 2480.00
250 μL * 10 mM (in DMSO) 4495.00
1 mg 4495.00
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Product Features

  • A unique collection of 155 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);
  • Targets include GRP78, IRE1, ATF6, PERK, etc.
  • Some compounds have been approved by FDA;
  • Structurally diverse, medicinally active, and cell permeable;
  • Rich documentation with chemical structure, target, and bioactivity information;
  • NMR and HPLC validated to ensure high purity.

Library Customization

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Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice
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