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Ubiquinol

Catalog No. T13243 CAS 992-78-9

Synonyms: Ubiquinol-10, CoQH2-10

Ubiquinol is a reduced form of coenzyme Q10 (CoQ10) and is a potent antioxidant that has the capacity to protect Vitamin E.

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Ubiquinol, CAS 992-78-9

Pack Size	Availability	Price/USD
500 μg	35 days	$ 296.00
1 mg	35 days	$ 545.00
5 mg	35 days	$ 2,400.00
10 mg	35 days	$ 4,200.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ubiquinol is a reduced form of coenzyme Q10 (CoQ10) and is a potent antioxidant that has the capacity to protect Vitamin E.
In vitro	The lipophilic environment encircles the lipophilic low-molecular-weight antioxidants (α-tocopherol, β-carotene, and Ubiquinol) and prevents them from reacting as skin protectors[1].
In vivo	The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular components isolated from the liver and kidney, and its ratio is approximately the same as the ratio of ubiquinol/t-UQ in the entire organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes[4].

Synonyms	Ubiquinol-10, CoQH2-10
Molecular Weight	865.381
Formula	C59H92O4
CAS No.	992-78-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Grammenandi K, et al. Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin. Skin Pharmacol Physiol. 2016;29(6):324-331. 2. Yamamoto Y, et al. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Mol Aspects Med. 1997;18 Suppl:S79-84. 3. Zhang Y, et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. 4. Takahashi T, et al. Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids. 1993 Sep;28(9):803-9.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ubiquinol 992-78-9 Others Ubiquinol-10 CoQH2-10 inhibitor inhibit

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