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Search Results for " spdb "

11

Compounds

Cat No. Product Name Synonyms Targets
T4346 SPDB Others
SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
T40762 NO2-SPDB-sulfo NO2-SPDB-sulfo
NO2-SPDB-sulfo is a cleavable linker vital in ADC synthesis. NO2-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optim...
T38682 Lys-Nε-SPDB-DM4 Lys-Nε-SPDB-DM4
Lys-Nε-SPDB-DM4 is a drug-linker conjugate that combines the tubulin inhibitor DM4 with the linker Lys-Nε-SPDB, facilitating the creation of an antibody-drug conjugate (ADC).
T18732 Sulfo-SPDB Others
sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing AD...
T40764 DMAC-SPDB
DMAC-SPDB is a cleavable linker vital in ADC synthesis. DMAC-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC ...
T40765 DMAC-SPDB-sulfo
DMAC-SPDB-sulfo is a cleavable linker vital in ADC synthesis. DMAC-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, opt...
T18701 SPDB-DM4 Others
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si...
T18703 SPDB-sulfo Others
SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1].
T18730 Sulfo-SPDB-DM4 Others
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.
T81060 Sulfo-SPDB-DGN462
Sulfo-SPDB-DGN462 is an agent-linker conjugate utilized for Antibody-Drug Conjugates (ADCs), featuring the potent DNA-alkylating agent DGN462 known for its anti-tumor properties, including efficacy against acute myeloid ...
T77907 Tusamitamab ravtansine HuMAb2-3-SPDB-DM4,SAR-408701
Tusamitamab ravtansine (SAR-408701) is a DM4-linked anti-CEACAM5 antibody-drug conjugate (ADC) comprising a humanized monoclonal antibody targeting carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) conj...
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