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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4346 | SPDB | Others | |
SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used. | |||
T40762 | NO2-SPDB-sulfo | NO2-SPDB-sulfo | |
NO2-SPDB-sulfo is a cleavable linker vital in ADC synthesis. NO2-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optim... | |||
T38682 | Lys-Nε-SPDB-DM4 | Lys-Nε-SPDB-DM4 | |
Lys-Nε-SPDB-DM4 is a drug-linker conjugate that combines the tubulin inhibitor DM4 with the linker Lys-Nε-SPDB, facilitating the creation of an antibody-drug conjugate (ADC). | |||
T18732 | Sulfo-SPDB | Others | |
sulfo-SPDB is a cleavable linker vital in ADC synthesis. sulfo-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing AD... | |||
T40764 | DMAC-SPDB | ||
DMAC-SPDB is a cleavable linker vital in ADC synthesis. DMAC-SPDB joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC ... | |||
T40765 | DMAC-SPDB-sulfo | ||
DMAC-SPDB-sulfo is a cleavable linker vital in ADC synthesis. DMAC-SPDB-sulfo joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, opt... | |||
T18701 | SPDB-DM4 | Others | |
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates si... | |||
T18703 | SPDB-sulfo | Others | |
SPDB-sulfo, a glutathione-cleavable linker, is utilized in the development of antibody-drug conjugates (ADCs) [1]. | |||
T18730 | Sulfo-SPDB-DM4 | Others | |
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker. | |||
T81060 | Sulfo-SPDB-DGN462 | ||
Sulfo-SPDB-DGN462 is an agent-linker conjugate utilized for Antibody-Drug Conjugates (ADCs), featuring the potent DNA-alkylating agent DGN462 known for its anti-tumor properties, including efficacy against acute myeloid ... | |||
T77907 | Tusamitamab ravtansine | HuMAb2-3-SPDB-DM4,SAR-408701 | |
Tusamitamab ravtansine (SAR-408701) is a DM4-linked anti-CEACAM5 antibody-drug conjugate (ADC) comprising a humanized monoclonal antibody targeting carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) conj... |