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Search Results for " eif2ak2 "

1

Compounds

13

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T74644 DB0614
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01556 EIF2AK2 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
EIF2AK2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is P19525.
TMPH-03672 Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO) VACV E. coli
Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain W...
TMPH-03671 Vaccinia virus (strain Western Reserve) K3 Protein (His) VACV P. pastoris (Yeast)
Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain W...
TMPH-02358 Influenza B (strain B/Lee/1940) Non-structural protein 1 (His) Influenza B E. coli
Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activa...
TMPH-03670 Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO) VACV E. coli
Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain C...
TMPH-03404 Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) Reo-3 E. coli
Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase...
TMPH-02349 Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc) H1N1 E. coli
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by...
TMPH-02209 TRAF5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation o...
TMPH-03415 Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc) RVFV E. coli
Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool...
TMPH-03732 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc) ZEBOV E. coli
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-03733 Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc) ZEBOV HEK293 Cells
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/...
TMPH-01552 IRF1 Protein, Human, Recombinant (GST & His) Human Baculovirus Insect Cells
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPH-01248 ADAR Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
EIF2AK2 Protein, Human, Recombinant (His)
TMPH-01556
Species: Human
Expression System: P. pastoris (Yeast)
Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)
TMPH-03672
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Western Reserve) K3 Protein (His)
TMPH-03671
Species: VACV
Expression System: P. pastoris (Yeast)
Influenza B (strain B/Lee/1940) Non-structural protein 1 (His)
TMPH-02358
Species: Influenza B
Expression System: E. coli
Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)
TMPH-03670
Species: VACV
Expression System: E. coli
Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)
TMPH-03404
Species: Reo-3
Expression System: E. coli
Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)
TMPH-02349
Species: H1N1
Expression System: E. coli
TRAF5 Protein, Human, Recombinant (His & SUMO)
TMPH-02209
Species: Human
Expression System: E. coli
Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)
TMPH-03415
Species: RVFV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
TMPH-03732
Species: ZEBOV
Expression System: E. coli
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
TMPH-03733
Species: ZEBOV
Expression System: HEK293 Cells
IRF1 Protein, Human, Recombinant (GST & His)
TMPH-01552
Species: Human
Expression System: Baculovirus Insect Cells
ADAR Protein, Human, Recombinant (His & SUMO)
TMPH-01248
Species: Human
Expression System: E. coli
TargetMol