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Pelacarsen

Catalog No. T78529 CAS 1637637-70-7

Synonyms: TQJ230, AKCEA-APO(a)-LRx, ISIS 681257

Pelacarsen (AKCEA-APO(a)-LRx) is a hepatotropic antisense oligonucleotide targeting apolipoprotein(a) that effectively attenuates lipoprotein(a) levels by up to 80% and exhibits favorable tolerability [1].

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Pelacarsen, CAS 1637637-70-7

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Description	Pelacarsen (AKCEA-APO(a)-LRx) is a hepatotropic antisense oligonucleotide targeting apolipoprotein(a) that effectively attenuates lipoprotein(a) levels by up to 80% and exhibits favorable tolerability [1].
In vivo	Mice treated weekly for six weeks with Pelacarsen at doses of 0.3, 1, 3, and 10 mg/kg exhibited dose-dependent decreases in target mRNA expression. The model-predicted ED50 (the dose for 50% of the maximal inhibitory effect) of Pelacarsen on liver apo(a) mRNA and plasma apo(a) protein levels were estimated to be 0.32 mg/kg/week and 0.54 mg/kg/week, respectively.

Synonyms	TQJ230, AKCEA-APO(a)-LRx, ISIS 681257
Molecular Weight	N/A
CAS No.	1637637-70-7

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pelacarsen 1637637-70-7 TQJ-230 ISIS681257 ISIS-681257 TQJ230 AKCEA-APO(a)-LRx ISIS 681257 TQJ 230 inhibitor inhibit

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