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N,N'-Diphenylguanidine

Name: N,N'-Diphenylguanidine
Brand: TargetMol
SKU: T20253
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20253Cas No. 102-06-7

Alias NSC-3272, NSC3272, NSC 3272

N,N'-Diphenylguanidine (NSC-3272) is an agent of biochemical.

N,N'-Diphenylguanidine

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Purity: 99.79%

Catalog No. T20253Alias NSC-3272, NSC3272, NSC 3272Cas No. 102-06-7

N,N'-Diphenylguanidine (NSC-3272) is an agent of biochemical.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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Purity:99.79%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

N,N'-Diphenylguanidine AI Summary

N,N'-Diphenylguanidine is a versatile bioactive compound with multiple inhibitory activities and interactions across various biological targets. It primarily inhibits [^3H]MK-801 radioligand binding to N-methyl-D-aspartate (NMDA) receptors in rat brain membranes with an IC50 of 3450.0 nM and [^3H]DTG radioligand binding to sigma receptors in guinea pig brain membranes with an IC50 of 397.0 nM. Additionally, it demonstrates inhibitory activity against sigma receptors with [^3H]-(+)-3-PPP binding (IC50 = 400.0 nM) and against [^3H]-TCP binding to PCP receptors (IC50 = 3450.0 nM). The compound also shows significant bioactivity in modulating various biological pathways and enzymes, including the inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), Polymerase Iota, and CYP450 2D6 enzyme, along with interactions with Sigma1 and Sigma2 receptors. It demonstrates inhibitory effects on Norepinephrine Transporter and is involved in various signaling pathways such as NF-kB, PXR, AhR, vitamin D receptor, and estrogen receptor alpha. In terms of antiviral properties, N,N'-Diphenylguanidine inhibits the cytotoxicity of cells infected with SARS-CoV-2 with effectiveness indicated by an IC50 value greater than 20000.0 nM and an observed inhibition of -6.79% in Caco-2 cells at 10 µM after 48 hours. It also shows a 15.31% inhibition rate of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, indicating potential antiviral activity. Moreover, N,N'-Diphenylguanidine exhibits moderate inhibition of human HDAC6 with a 15.46% inhibition rate using a commercial peptide substrate, highlighting its potential as a multifaceted agent in therapeutic research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N,N'-Diphenylguanidine (NSC-3272) is an agent of biochemical.
Synonyms	NSC-3272, NSC3272, NSC 3272

Chemical Properties

Molecular Weight	211.26
Formula	C₁₃H₁₃N₃
Cas No.	102-06-7
Smiles	N=C(NC1=CC=CC=C1)NC1=CC=CC=C1
Relative Density.	Ca. 0.348. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (307.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7335 mL	23.6675 mL	47.3350 mL	236.6752 mL
5 mM	0.9467 mL	4.7335 mL	9.4670 mL	47.3350 mL
10 mM	0.4734 mL	2.3668 mL	4.7335 mL	23.6675 mL
20 mM	0.2367 mL	1.1834 mL	2.3668 mL	11.8338 mL
50 mM	0.0947 mL	0.4734 mL	0.9467 mL	4.7335 mL
100 mM	0.0473 mL	0.2367 mL	0.4734 mL	2.3668 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc