Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mipomersen (sodium), a second-generation, 20-base phosphorothioate antisense oligonucleotide (ASO), targets human apoB-100.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 1,550.00 | |
10 mg | Inquiry | $ 2,320.00 |
Description | Mipomersen (sodium), a second-generation, 20-base phosphorothioate antisense oligonucleotide (ASO), targets human apoB-100. |
In vitro | Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2]. Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2]. |
Molecular Weight | N/A |
CAS No. | 629167-92-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mipomersen sodium 629167-92-6 inhibitor inhibit