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ICI 199,441 hydrochloride

Name: ICI 199,441 hydrochloride
Brand: TargetMol
SKU: T22849
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22849Cas No. 115199-84-3

ICI 199,441 hydrochloride is a potent, selective agonist of κ-opioid receptor.

ICI 199,441 hydrochloride

🥰Excellent

Purity: 99.57%

Catalog No. T22849Cas No. 115199-84-3

ICI 199,441 hydrochloride is a potent, selective agonist of κ-opioid receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$148	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$349	In Stock	In Stock
200 mg	$490	-	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ICI 199,441 hydrochloride is a potent, selective agonist of κ-opioid receptor.
In vivo	Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect in Wistar rats[1].

Chemical Properties

Molecular Weight	427.8
Formula	C₂₁H₂₅Cl₃N₂O
Cas No.	115199-84-3
Smiles	Cl.CN([C@H](CN1CCCC1)c1ccccc1)C(=O)Cc1ccc(Cl)c(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (525.95 mM), Sonication is recommended.

Ethanol: 50 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3375 mL	11.6877 mL	23.3754 mL	116.8770 mL
5 mM	0.4675 mL	2.3375 mL	4.6751 mL	23.3754 mL
10 mM	0.2338 mL	1.1688 mL	2.3375 mL	11.6877 mL
20 mM	0.1169 mL	0.5844 mL	1.1688 mL	5.8439 mL
50 mM	0.0468 mL	0.2338 mL	0.4675 mL	2.3375 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0234 mL	0.1169 mL	0.2338 mL	1.1688 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc