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GSK-3β inhibitor 6

Catalog No. T61804

GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GSK-3β inhibitor 6, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
In vitro	GSK-3β inhibitor 6 (Compound B30, 0-30 μΜ, 30 min) demonstrates effective GSK-3β kinase inhibition (IC 50: 24.4 μM) while also significantly enhancing hepatocyte glucose uptake by 38% (5 μM, 3 h) without notable toxicity to HepG2 cells [1].
In vivo	GSK-3β inhibitor 6 (Compound 5k), administered orally at 20 mg/kg, demonstrates favorable pharmacokinetics, including a half-life (t 1/2) of 1.41 hours and a peak concentration (C max) of 288 ng/mL in Sprague-Dawley rats used for pharmacokinetic assessment. The study explored two administration routes: intravenous injection at 2 mg/kg and oral delivery at 20 mg/kg. The pharmacokinetic outcomes reveal that the oral administration of GSK-3β inhibitor 6 results in a half-life of 1.41 hours, time to peak concentration (Tmax) of 1.33 hours, and oral bioavailability (F) of 11.4%. In contrast, intravenous injection exhibits a slightly longer half-life of 2.13 hours and a quicker Tmax of 0.08 hours, underscoring the influence of administration routes on the compound's pharmacokinetic profile.

Molecular Weight	393.28
Formula	C20H17BrN4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GSK-3β inhibitor 6 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.