keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA, a potent peptide antagonist, selectively targets and binds to the FZD7 CRD subclass, significantly altering its CRD conformation and the structure of its lipid-binding groove. This compound exhibits EC50 values of 58 nM for human FZD7 CRD and 34 nM for mouse FZD7 CRD, demonstrating its effectiveness. Crucially, Fz7-21 TFA disrupts FZD7's role in Wnt-β-catenin signaling and stem cell functionality within intestinal organoids [1] [2].
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Description | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA, a potent peptide antagonist, selectively targets and binds to the FZD7 CRD subclass, significantly altering its CRD conformation and the structure of its lipid-binding groove. This compound exhibits EC50 values of 58 nM for human FZD7 CRD and 34 nM for mouse FZD7 CRD, demonstrating its effectiveness. Crucially, Fz7-21 TFA disrupts FZD7's role in Wnt-β-catenin signaling and stem cell functionality within intestinal organoids [1] [2]. |
Molecular Weight | 1910.07 |
Formula | C85H115N18F3O25S2 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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