Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | Inquiry | |
50 mg | 10-14 weeks | Inquiry |
Description | DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitor. |
In vitro | Buthionine sulfoximine is an analog of methionine sulfoximine that inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine [1]. |
In vivo | Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors. Under these treatment conditions, a combination of D,L-Buthionine-(S,R)-sulfoximine with the maximum tolerated dose of doxorubicin administered at 24 h during a 48-h i.v. infusion of D,L-Buthionine-(S,R)-sulfoximine completely restored the response of MRP-expressing HT1080/DR4 tumors to doxorubicin (overall response rate, 63%; complete response rate, 38%) with no potentiation of host toxicity [2]. |
Molecular Weight | 258.77 |
Formula | C8H19ClN2O3S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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DL-Buthionine-(S,R)-sulfoximine hydrochloride inhibitor inhibit