Powder: -20°C for 3 years | In solvent: -80°C for 1 year
D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 970.00 |
Description | D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase. |
In vitro | D,L-erythro-PDMP at concentrations of 0, 12, 25, 50 μM over periods of 0, 4, 7, and 10 days demonstrates a dose-dependent inhibition of rabbit skin fibroblast proliferation, as evidenced by reduced cell growth[1]. A concentration of 50 μM of D,L-erythro-PDMP, when applied for 3 days, results in cytotoxic effects, altering the cell morphology of rabbit skin fibroblasts[1]. Furthermore, treatment with D,L-erythro-PDMP at a concentration of 40 μM for 24 hours in MDCK cells leads to a significant increase in glucosyltransferase activity, quantified at 14.6 nmol/h per mg of protein[2]. Additionally, a 40 μM concentration of D,L-erythro-PDMP administered for 6 hours offers protective effects against synthase loss in cells challenged with cycloheximide[2]. These findings are supported by cell proliferation and cytotoxicity assays on rabbit skin fibroblast cell lines, illustrating D,L-erythro-PDMP's capacity to modulate cell growth and viability in a concentration and time-dependent manner[1]. |
Molecular Weight | 390.568 |
Formula | C23H38N2O3 |
CAS No. | 109760-77-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
D,L-erythro-PDMP 109760-77-2 D,LerythroPDMP D,L erythro PDMP inhibitor inhibit