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CB2R/FAAH modulator-1

CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively.

Catalog No. T67896Cas No. 928892-60-8

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Purity:100%

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COA HNMR HPLC

CB2R/FAAH modulator-1

Catalog No. T67896Cas No. 928892-60-8

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Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$268	In Stock
10 mg	$394	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	$2,260	In Stock
1 mL x 10 mM (in DMSO)	$277	In Stock

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Product Introduction

Bioactivity

Description	CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively.
Targets&IC50	FAAH:4 μM, CB2 receptor:14.8 nM(Kis), CB1 receptor:241.3 nM(Kis)
In vitro	CB2R/FAAH modulator-1 (compound 13; 10 μM; 24 h) reduces TNFα, IFN-γ, IL-1β, and IL-6 production in unstimulated monocytes and macrophages[1].

Chemical Properties

Molecular Weight	361.48
Formula	C₂₄H₂₇NO₂
Cas No.	928892-60-8

Storage & Solubility Information

Storage

Shipping with blue ice.

Solubility Information

DMSO: 11 mg/mL (30.43 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7664 mL	13.8320 mL	27.6640 mL	138.3202 mL
5 mM	0.5533 mL	2.7664 mL	5.5328 mL	27.6640 mL
10 mM	0.2766 mL	1.3832 mL	2.7664 mL	13.8320 mL
20 mM	0.1383 mL	0.6916 mL	1.3832 mL	6.9160 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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