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Zileuton sodium

Catalog No. T21836 CAS 118569-21-4

Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.

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Zileuton sodium, CAS 118569-21-4

Pack Size	Availability	Price/USD	Quantity
5 mg	5 days	$ 30.00
10 mg	5 days	$ 49.00

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Biological Description

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Description	Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.
In vitro	In cells treated with anti-CD3, IL-2 levels decrease over time both in the presence and absence of Zileuton sodium (A 64077 sodium). Zileuton sodium may reduce IL-2 concentrations by inhibiting 5-lipoxygenase, thereby decreasing leukotriene B4 production, which is known to induce IL-2 [2].
In vivo	In rats undergoing ischemia/reperfusion (I/R), treatment with Zileuton sodium (A 64077 sodium) (5 mg/kg, p.o.) does not significantly alter NF-κB expression levels in the presence of COX inhibitors, yet it notably decreases NF-κB staining. This same dosage of Zileuton significantly lowers the apoptotic index in I/R rats, though it doesn't affect raised serum TNF-α levels [1]. Additionally, at a dosage of 1200 mg/kg, Zileuton sodium effectively inhibits polyp formation in the APC Δ468 mutation of the colon and small intestine. It reduces proliferation rates of non-epithelial cells in polyps while elevating apoptosis rates, leading to a significant increase in apoptotic cell numbers in both sites. This reduction in cell proliferation contributes substantially to the decreased polyposis in the small intestine and colon of Zileuton-fed APC Δ468 mice [3].

Molecular Weight	258.27
Formula	C11H11N2NaO2S
CAS No.	118569-21-4

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zileuton sodium 118569-21-4 inhibitor inhibit

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