Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors, exhibits IC50 values of 1.8 nM for A1 and 114 nM for A2 receptors. Additionally, it functions as a convulsant agent in mouse models.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 35 days | $ 468.00 | |
50 mg | 35 days | $ 1,940.00 |
Description | Xanthine amine congener dihydrochloride (XAC dihydrochloride), a potent antagonist for both Adenosine A1 and A2 receptors, exhibits IC50 values of 1.8 nM for A1 and 114 nM for A2 receptors. Additionally, it functions as a convulsant agent in mouse models. |
Targets&IC50 | A1 receptor:1.8 nM (IC50), A2 receptor:114 nM (IC50) |
In vivo | Xanthine amine congener dihydrochloride (XAC) demonstrates greater potency as a convulsant agent compared to caffeine or theophylline when administered through infusion at a dosage of 39.8 mg/kg. However, XAC exhibits no convulsant effects when delivered via intraperitoneal (i.p.) injection, with the seizure threshold exceeding 1000 mg/kg. This observation is supported by studies conducted on mice, utilizing a single infusion injection of 39.8 mg/kg, thereby positioning XAC as a more potent convulsant than either caffeine or theophylline under specified conditions. [1] |
Synonyms | XAC dihydrochloride, Xanthine amine congener dihydrochloride |
Molecular Weight | 501.41 |
Formula | C21H30Cl2N6O4 |
CAS No. | 1962928-23-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Xanthine amine congener dihydrochloride 1962928-23-9 Xanthine amine congener XAC dihydrochloride XAC Dihydrochloride Xanthine amine congener Dihydrochloride XAC inhibitor inhibit