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Xanomeline tartrate

Catalog No. T39010 CAS 152854-19-8

Synonyms: LY 246708 tartrate, Xanomeline tartrate

Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia.

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Xanomeline tartrate, CAS 152854-19-8

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2 mg	5 days	$ 31.00

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Description	Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia.
In vitro	Xanomeline (LY 246708), within the concentration range of 0.1-10 μM for CNS4U, demonstrates an enhancement in the mean firing rate, affirming the functionality of the M1 receptor in hiPSC-derived neurons. At concentrations exceeding 1 μM, xanomeline engages with the receptor over an extended period, resulting in continuous receptor activation and sustained suppression of the M-current[1].
In vivo	Administered subcutaneously at doses ranging from 0.5 to 3 mg/kg for 1 to 3 hours, Xanomeline (LY 246708) triggered salivation and vomiting in certain male Cebus apella monkeys. The compound exhibits functional dopamine antagonism and an antipsychotic-like effect, effectively inhibiting D-amphetamine- and (?)-apomorphine-induced behaviors without causing extrapyramidal side effects.

Synonyms	LY 246708 tartrate, Xanomeline tartrate
Molecular Weight	431.5
Formula	C18H29N3O7S
CAS No.	152854-19-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kreir M, et al. Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. Eur J Pharmacol. 2019;858:172474. 2. Shekhar A, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 2008;165(8):1033-1039.

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Keywords

Xanomeline tartrate 152854-19-8 LY 246708 Tartrate LY246708 Tartrate LY-246708 Tartrate LY 246708 tartrate Xanomeline Tartrate inhibitor inhibit

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