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XL413 hydrochloride

Catalog No. T6735 CAS 2062200-97-7

Synonyms: XL413, BMS-863233 Hydrochloride, BMS-863233

XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, <a href="/target/Pim" style="display: inline; color: #c13a36">Pim</a>1, respectively, and an EC 50 of 118 nM on pMCM.

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XL413 hydrochloride, CAS 2062200-97-7

Pack Size	Availability	Price/USD	Quantity
200 mg	In stock	$ 1,168.00
500 mg	In stock	$ 2,222.00

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Purity: 99.82%

Purity: 99.8%

Purity: 99%

Purity: 98.81%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.
Targets&IC50	CK2:212 nM, Pim1:42 nM, Cdc7:3.4 nM
In vitro	XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC 50 =2685 nM), decreases cell viability (IC 50 =2142 nM) and elicits the caspase 3/7 activity (EC 50 =2288 nM) in Colo-205 cells. XL413 hydrochloride also markedly inhibits the anchorage-independent growth of colo-205 in soft agar (IC 50 =715 nM) [1]. XL413 hydrochloride exhibits cytotoxic effects on tumors, with IC 50 of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. XL413 hydrochloride induces apoptosis in the Colo-205 cells, while not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC 50 of 22.7 nM. XL413 hydrochloride is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells [2].
In vivo	XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride exhibits excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses without significant body weight loss [1].

Synonyms	XL413, BMS-863233 Hydrochloride, BMS-863233
Molecular Weight	326.18
Formula	C14H13Cl2N3O2
CAS No.	2062200-97-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Koltun ES, et al. Bioorg Med Chem Lett. 2012, 22(11), 3727-3731.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Liver Cancer Compound Library Immunology/Inflammation Compound Library JAK-STAT Compound Library Drug Repurposing Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Drug Library Reprogramming Compound Library Neuronal Signaling Compound Library Stem Cell Differentiation Compound Library GPCR Compound Library

Related Products

Related compounds with same targets

Epiblastin A Ellagic acid (hydrate) NCC007 SR-3029 CK2 inhibitor 2 Emodin CKI-7 TTP 22

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Keywords

XL413 hydrochloride 2062200-97-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein JAK/STAT signaling Metabolism Stem Cells Casein Kinase Pim cholecystokinin CDK XL413 XL-413 hydrochloride BMS-863233 Hydrochloride BMS-863233 Inhibitor inhibitor inhibit

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