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XL413 hydrochloride

Catalog No. T6735 CAS 2062200-97-7

Synonyms: BMS-863233 Hydrochloride, XL413, BMS-863233

XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.

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XL413 hydrochloride, CAS 2062200-97-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 117.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 747.00
200 mg	In stock	$ 987.00
500 mg	In stock	$ 1,520.00
1 mL * 5 mM (in DMSO)	In stock	$ 163.00

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Purity: 99.82%

Purity: 99.8%

Purity: 99%

Purity: 98.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.
Targets&IC50	CDC7:3.4 nM, Pim1:42 nM, CK2:212 nM
In vitro	XL413 (BMS-863233) hydrochloride effectively inhibits cell proliferation (IC 50 = 2685 nM), reduces cell viability (IC 50 = 2142 nM), and increases caspase 3/7 activity (EC 50 = 2288 nM) in Colo-205 cells. Additionally, it significantly suppresses the anchorage-independent growth of Colo-205 cells in soft agar (IC 50 = 715 nM) [1]. Demonstrating cytotoxic effects, XL413 hydrochloride has IC 50 values of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. It triggers apoptosis in Colo-205 cells without affecting HCC1954 cells. As a DDK inhibitor, XL413 shows potent activity in vitro (IC 50 = 22.7 nM), yet fails to inhibit DDK-dependent Mcm2 phosphorylation in HCC1954 cells, while remaining effective in Colo-205 cells [2].
In vivo	XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride exhibits excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses without significant body weight loss [1].

Synonyms	BMS-863233 Hydrochloride, XL413, BMS-863233
Molecular Weight	326.18
Formula	C14H13Cl2N3O2
CAS No.	2062200-97-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mg/mL (7.66 mM)

H2O: 4.76 mg/mL (14.6 mM), Sonification is recommended

References and Literature

1. Koltun ES, et al. Bioorg Med Chem Lett. 2012, 22(11), 3727-3731.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library JAK-STAT Compound Library Anti-Metabolism Disease Compound Library Orally Active Compound Library Reprogramming Compound Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

XL413 hydrochloride 2062200-97-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein JAK/STAT signaling Metabolism Stem Cells CDK cholecystokinin Casein Kinase Pim BMS-863233 Hydrochloride XL-413 hydrochloride XL 413 Hydrochloride XL413 BMS 863233 Hydrochloride BMS863233 Hydrochloride BMS863233 XL 413 XL-413 Hydrochloride XL-413 XL413 Hydrochloride BMS 863233 BMS-863233 inhibitor inhibit

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