Powder: -20°C for 3 years
In solvent: -80°C for 2 years
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, <a href="/target/Pim" style="display: inline; color: #c13a36">Pim</a>1, respectively, and an EC 50 of 118 nM on pMCM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
200 mg | In stock | $ 1,168.00 | |
500 mg | In stock | $ 2,222.00 |
Description | XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM. |
Targets&IC50 | CK2:212 nM, Pim1:42 nM, Cdc7:3.4 nM |
In vitro | XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC 50 =2685 nM), decreases cell viability (IC 50 =2142 nM) and elicits the caspase 3/7 activity (EC 50 =2288 nM) in Colo-205 cells. XL413 hydrochloride also markedly inhibits the anchorage-independent growth of colo-205 in soft agar (IC 50 =715 nM) [1]. XL413 hydrochloride exhibits cytotoxic effects on tumors, with IC 50 of 22.9 μM in HCC1954 cells and 1.1 μM in Colo-205 cells. XL413 hydrochloride induces apoptosis in the Colo-205 cells, while not in HCC1954 cells. XL413 is effective DDK inhibitors in vitro, with IC 50 of 22.7 nM. XL413 hydrochloride is defective in inhibiting DDK-dependent Mcm2 phosphorylation in HCC1954 cells but is effective in Colo-205 cells [2]. |
In vivo | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride exhibits excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses without significant body weight loss [1]. |
Synonyms | XL413, BMS-863233 Hydrochloride, BMS-863233 |
Molecular Weight | 326.18 |
Formula | C14H13Cl2N3O2 |
CAS No. | 2062200-97-7 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 10mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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XL413 hydrochloride 2062200-97-7 Cell Cycle/Checkpoint Chromatin/Epigenetic GPCR/G Protein JAK/STAT signaling Metabolism Stem Cells Casein Kinase Pim cholecystokinin CDK XL413 XL-413 hydrochloride BMS-863233 Hydrochloride BMS-863233 Inhibitor inhibitor inhibit