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Vicenin 2

Catalog No. T3851   CAS 23666-13-9
Synonyms: Vicenin -2

Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.

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Vicenin 2 Chemical Structure
Vicenin 2, CAS 23666-13-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 79.00
5 mg In stock $ 122.00
10 mg In stock $ 213.00
25 mg In stock $ 359.00
50 mg In stock $ 535.00
1 mL * 10 mM (in DMSO) In stock $ 166.00
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Purity: 99.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
Targets&IC50 ACE:43.83 μM
In vitro Lychnophora salicifolia, commonly known as 'arnicão', is used as an anti-inflammatory agent and as a flavoring agent in the Brazilian traditional spirit 'cachaça'.METHODS AND RESULTS: In this work, the permeation process of Vicenin -2 (1) and lychnopholic acid (2) (major secondary metabolites from the hydroalcoholic extract) was investigated using Caco-2 cells. For this investigation, a new HPLC-DAD method was developed and validated for the quantification step. It was observed that 2 crosses the Caco-2 cell monolayer by passive diffusion. On the other hand, 1 was not transported, suggesting no absorption and no efflux of this compound in Caco-2 cells.
Synonyms Vicenin -2
Molecular Weight 594.52
Formula C27H30O15
CAS No. 23666-13-9

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (92.51 mM)

TargetMolReferences and Literature

1. Evaluation of intestinal permeability of vicenin-2 and lychnopholic acid from Lychnophora salicifolia (Brazilian arnicão) using Caco-2 cells. J Nat Prod. 2014 Mar 28;77(3):464-71.

Related compound libraries

This product is contained In the following compound libraries:
Marine Natural Product Library Anti-Cancer Active Compound Library Selected Plant-Sourced Compound Library Anti-Diabetic Compound Library Polyphenolic Natural Product Library Inhibitor Library Anti-Hypertension Compound Library Oxidation-Reduction Compound Library Bioactive Compounds Library Max Traditional Chinese Medicine Monomer Library

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Keywords

Vicenin 2 23666-13-9 Endocrinology/Hormones RAAS Vicenin -2 inhibit Vicenin2 Angiotensin-converting Enzyme (ACE) Inhibitor Vicenin-2 inhibitor

 

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