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Vandetanib Fumarate

Catalog No. T1656L CAS 338992-00-0

Synonyms: HSDB 8198, Zactima, Caprelsa, ZD 6474, Vandetanib

Vandetanib Fumarate is an orally available tyrosine kinase inhibitor. Vandetanib Fumarate works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epidermal growth factor receptor and to a lesser extent VEGFR-1, which are important targets in thyroid cancer (TC).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Vandetanib Fumarate, CAS 338992-00-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	HSDB 8198, Zactima, Caprelsa, ZD 6474, Vandetanib
Molecular Weight	591.43
Formula	C26H28BrFN4O6
CAS No.	338992-00-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fallahi P, Di Bari F, Ferrari SM, Spisni R, Materazzi G, Miccoli P, Benvenga S, Antonelli A. Selective use of vandetanib in the treatment of thyroid cancer. Drug Des Devel Ther. 2015 Jul 3;9:3459-70. doi: 10.2147/DDDT.S72495. eCollection 2015. Review. PubMed PMID: 26170630; PubMed Central PMCID: PMC4498730. 2. Cooper MR, Yi SY, Alghamdi W, Shaheen DJ, Steinberg M. Vandetanib for the treatment of medullary thyroid carcinoma. Ann Pharmacother. 2014 Mar;48(3):387-94. doi: 10.1177/1060028013512791. Epub 2013 Nov 14. Review. PubMed PMID: 24259657. 3. Fallahi P, Ferrari SM, Baldini E, Biricotti M, Ulisse S, Materazzi G, Miccoli P, Antonelli A. The safety and efficacy of vandetanib in the treatment of progressive medullary thyroid cancer. Expert Rev Anticancer Ther. 2016 Nov;16(11):1109-1118. Epub 2016 Sep 30. Review. PubMed PMID: 27650489. 4. De Luca A, D'Alessio A, Maiello MR, Gallo M, Bevilacqua S, Frezzetti D, Morabito A, Perrone F, Normanno N. Vandetanib as a potential treatment for breast cancer. Expert Opin Investig Drugs. 2014 Sep;23(9):1295-303. doi: 10.1517/13543784.2014.942034. Epub 2014 Aug 4. Review. PubMed PMID: 25089348.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vandetanib Fumarate 338992-00-0 ZD6474 ZD-6474 HSDB8198 HSDB 8198 Zactima Caprelsa HSDB-8198 ZD 6474 Vandetanib inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.