Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UZH1a is a potent and selective inhibitor of METTL3, exhibiting an IC50 of 280 nM. It serves as a tool for epitranscriptomic modulation of cellular processes and possesses antitumor activity. Additionally, UZH1a functions as a chemical probe for the study of METTL3[1].
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5 mg | Inquiry | $ 946.00 |
Description | UZH1a is a potent and selective inhibitor of METTL3, exhibiting an IC50 of 280 nM. It serves as a tool for epitranscriptomic modulation of cellular processes and possesses antitumor activity. Additionally, UZH1a functions as a chemical probe for the study of METTL3[1]. |
In vitro | UZH1a (2.5-160 μM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 μM, 67 μM, and 87 μM, respectively[1].UZH1a (2.5-100 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13 cells in a dose-dependent manner (IC50=4.6 μM)[1].UZH1a (40 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].UZH1a (20 μM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1]. |
Molecular Weight | N/A |
CAS No. | 2813577-78-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (143.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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UZH1a 2813577-78-3 UZH-1a inhibitor inhibit