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UMB298

Catalog No. T9194 CAS 2266569-73-5

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.

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UMB298, CAS 2266569-73-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 118.00
5 mg	In stock	$ 291.00
10 mg	In stock	$ 482.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
Targets&IC50	BRD4:5193nM
In vitro	UMB298 inhibits MOLM13 and MM cells growth. UMB298 reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 down-regulates MYC expression in MOLM13 cells.

Molecular Weight	479.01
Formula	C27H31ClN4O2
CAS No.	2266569-73-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL(41.75 mM), Sonication is recommended.

References and Literature

1. Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors[J]. Journal of medicinal chemistry, 64(9):5787-5801.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Reprogramming Compound Library NO PAINS Compound Library Histone Modification Compound Library Bioactive Compounds Library Max Bioactive Compound Library Epigenetics Compound Library PPI Inhibitor Library

Related Products

Related compounds with same targets

SMD-3040 OXFBD04 Naphthol AS-E PBRM1-BD2-IN-7 Cycloastragenol BRD4 degrader AT1 ML367 Bromodomain inhibitor-12 (edisylate)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UMB298 2266569-73-5 Chromatin/Epigenetic Epigenetic Reader Domain inhibit MOLM13 Inhibitor bromodomain UMB-298 selective potent UMB 298 CBP30 inhibitor

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