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Tubulin inhibitor 17

Catalog No. T60436

Tubulin inhibitor 17 (Compound 3b) is an inhibitor of tubulin polymerization (IC50 = 12.38 µM). Tubulin inhibitor 17 exhibits anticancer activities as well as induces cell apoptosis[1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tubulin inhibitor 17, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tubulin inhibitor 17 (Compound 3b) is an inhibitor of tubulin polymerization (IC50 = 12.38 µM). Tubulin inhibitor 17 exhibits anticancer activities as well as induces cell apoptosis[1].

In vitro

Tubulin inhibitor 17 (Compound 3b) (0-10 μM, 0-72 h) shows antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells [1]. Tubulin inhibitor 17 (0-2.5 μM) concentration dependently inhibits tubulin polymerization[1]. Tubulin inhibitor 17 (0-1 μM, 12 h) dose-dependently induces the collapse of the microtubule networks[1]. Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase as well as inhibits cell migration of HepG-2 cells [1]. Tubulin inhibitor 17 (0-5 μM, 48 h) induces apoptosis in HepG-2 cells [1]. Cell Proliferation Assay [1] Cell Line: B16-F10, HepG-2, Hela and MCF-7 Concentration: 0, 0.5, 2.5, 5.0, 7.5 and 10 μM Incubation Time: 48 h for IC 50 measurement, 0-72 h for cell viability Result: Demonstrated antiproliferative activities with IC 50 values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 μM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a concentration- and time-dependent manner. Cell Cycle Analysis [1] Cell Line: HepG-2 Concentration: 0.5, 1.0 and 5.0 μM Incubation Time: 24 h Result: Dose-dependent induction of cell cycle arrest in G2/M phase. Apoptosis Analysis [1] Cell Line: HepG-2 Concentration: 0.5, 1.0 and 5.0 μM Incubation Time: 48 h Result: The overall proportion of apoptotic cells was significantly increased compared to the control.

Molecular Weight	264.32
Formula	C17H16N2O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tubulin inhibitor 17 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.