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Catalog No. T3468   CAS 1849590-01-7
Synonyms: eFT508

eFT508 is a potent, highly selective <a href="/target/MNK" style="display: inline; color: #c13a36">MNK</a>1 and <a href="/target/MNK" style="display: inline; color: #c13a36">MNK</a>2 inhibitor with IC50 value of 1-2 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Tomivosertib, CAS 1849590-01-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 73.00
5 mg In stock $ 194.00
10 mg In stock $ 284.00
25 mg In stock $ 499.00
50 mg In stock $ 858.00
100 mg In stock $ 1,219.00
1 mL * 10 mM (in DMSO) In stock $ 212.00
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Purity: 98%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description eFT508 is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.
Targets&IC50 MNK1:1-2 nM, MNK2:1-2 nM
In vitro eFT508 has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. Treatment of tumor cell lines with eFT508 leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50 = 2-16 nM). In a panel of ~50 hematological cancers, eFT508 shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to eFT508 in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10[1].
In vivo eFT508 is well-tolerated and shows efficacy against MyD88-mutant DLBCL models in vivo. Significant anti-tumor activity of eFT508 is observed in the TMD8 and HBL-1 ABC-DLBCL models(subcutaneous human lymphoma xenograft models), both of which harbor activating MyD88 mutations[1].
Cell Research TMD8 cells are treated with the indicated concentrations of eFT508 for 24 h. Cell lysates are subjected to m7-GTP Sepharose pull-down and bound proteins are analyzed by immunoblotting with the indicated antibodies. (Only for Reference)
Synonyms eFT508
Molecular Weight 340.387
Formula C17H20N6O2
CAS No. 1849590-01-7


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 11 mg/mL (32.3 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kevin R Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL). Abstract#1554. 2. Suarez M, Blyth G T, Mina A A, et al. Inhibitory effects of Tomivosertib in acute myeloid leukemia[J]. Oncotarget. 2021, 12(10): 955.


1. Suarez M, Blyth G T, Mina A A, et al. Inhibitory effects of Tomivosertib in acute myeloid leukemia. Oncotarget. 2021, 12(10): 955.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Immuno-Oncology Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Hematonosis Compound Library Anti-Colorectal Cancer Compound Library NO PAINS Compound Library Anti-Prostate Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


Tomivosertib 1849590-01-7 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation MAPK PD-1/PD-L1 MNK Inhibitor MAP kinase interacting kinase Mitogen activated protein kinase interacting kinase MAPK interacting kinase eFT-508 eFT508 eFT 508 inhibit inhibitor