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Tirofiban HCl

Catalog No. T20552 CAS 142373-60-2

Synonyms: MK 383, Aggrastat, MK383, MK-383, Tirofiban hydrochloride

Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.

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Tirofiban HCl, CAS 142373-60-2

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.

Synonyms	MK 383, Aggrastat, MK383, MK-383, Tirofiban hydrochloride
Molecular Weight	477.06
Formula	C22H37ClN2O5S
CAS No.	142373-60-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Bergquist PA, Hunke WA, Reed RA, Manas D, Forsyth RJ, Kenney RR, Cook J, Holahan M. Compatibility of tirofiban HCl with dopamine HCl, famotidine, sodium heparin, lidocaine HCl and potassium chloride during simulated Y-site administration. J Clin Pharm Ther. 1999 Apr;24(2):125-32. PubMed PMID: 10380064. 2. Saucedo JF, Garza L, Wolford DC, Cook SL, Ramanathan KB, Matin Z, McGrew FA, Jacoski MV, Jennings LK; Tennessee-Arkansas-Mississippi (TAM) Clinical Research Consortium. Comparative pharmacodynamic evaluation of eptifibatide and tirofiban HCl in patients undergoing percutaneous coronary intervention (the TAM1 Study). Am J Cardiol. 2004 May 15;93(10):1279-82. PubMed PMID: 15135704. 3. Yates YJ, Farias CL, Kazmier FR, Puckett CL, Concannon MJ. The effect of tirofiban on microvascular thrombosis: crush model. Plast Reconstr Surg. 2005 Jul;116(1):205-8. PubMed PMID: 15988269. 4. El-Bagary RI, Elkady EF, Farid NA, Youssef NF. Validated spectrofluorimetric methods for the determination of apixaban and tirofiban hydrochloride in pharmaceutical formulations. Spectrochim Acta A Mol Biomol Spectrosc. 2017 Mar 5;174:326-330. doi: 10.1016/j.saa.2016.11.048. Epub 2016 Dec 3. Erratum in: Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jun 15;181:23. PubMed PMID: 27984753.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tirofiban HCl 142373-60-2 MK 383 Aggrastat MK383 MK-383 Tirofiban hydrochloride Tirofiban Hydrochloride inhibitor inhibit

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